abstract：OBJECTIVES:Naloxone is indicated for reversal of opioid-induced respiratory depression. The objective of this study is to evaluate patterns of naloxone use in hospitalized patients. METHODS:Retrospective chart review at the University of California, San Diego Health. Subjects included adults ≥18 years old who were adm...

journal_title：Postgraduate medicine

authors： Yung L,Lee KC,Hsu C,Furnish T,Atayee RS

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:This study aims to compare the effectiveness of insulin glargine 300 U/mL (Gla-300) with its accompanying patient support program with that of other basal insulin and available patient support programs in patients with type 2 diabetes (T2D) in a real-world setting in terms of achieving HEDIS (Healthcare Effec...

journal_title：Postgraduate medicine

authors： Oster G,Sullivan SD,Dalal MR,Kazemi MR,Rojeski M,Wysham CH,Sung J,Johnstone B,Cali AM,Wei LJ,Traylor L,Anhalt H,Hull M,Van Vleet J,Meneghini LF

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVES:Our aim was to investigate the association of liver fibrosis and necroinflammation with HS in untreated young patients with chronic hepatitis B (CHB). MATERIALS AND METHODS:A retrospective study was conducted in a military hospital in Turkey. A total of 254 subjects with CHB were included in this study. The...

journal_title：Postgraduate medicine

authors： Karacaer Z,Okur G,Cermik H,Altun D

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVES:To investigate the associations of major and subthreshold depression with all-cause, cardiovascular disease and stroke mortality, and the extent to which health behaviour, medical comorbidity and functional disability explained the associations. METHODS:A cohort of 1070 persons aged ≥60 with Geriatric Menta...

journal_title：Postgraduate medicine

authors： Ho CSh,Jin A,Nyunt MS,Feng L,Ng TP

更新日期：2016-09-01 00:00:00

abstract：:Nearly 1 in 5 Americans will struggle with major depression in their lives; some will have recurring bouts. Recent psychiatric research has given new attention to the prevalence of cognitive deficits in major depression and the impact such deficits have on remission and overall life functioning. When depression is par...

journal_title：Postgraduate medicine

authors： Mattingly G,Anderson RH,Mattingly SG,Anderson EQ

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVES:There is limited and contradictory information regarding the role of serum ischemia-modified albumin (IMA) in obstructive sleep apnea (OSA). In this study we examine the effects of OSA and obesity on IMA and interleukin-6 (IL-6), and detect whether IMA and IL-6 may be potential biomarkers in OSA. METHODS:Fi...

journal_title：Postgraduate medicine

authors： Dogan D,Ocal N,Aydogan M,Tasci C,Arslan Y,Tapan S,Yetkin S,Bilgic H

更新日期：2016-08-01 00:00:00

abstract：:Common variable immunodeficiency (CVID) is readily considered in patients presenting with recurrent sino-pulmonary infections, however this disease has a broad range of clinical manifestations and diagnosis can be delayed by several years. We present the case of a 44-year-old postpartum female who presented with nause...

journal_title：Postgraduate medicine

authors： Arays R,Goyal S,Jordan KM

更新日期：2016-08-01 00:00:00

abstract：:Pulmonary artery hypertension (PAH) refers to several subgroups of disease in which the mean pulmonary artery pressure (mPAP) is elevated to more than 25 mm Hg, pulmonary artery wedge pressure (PAWP) ≤ 15 mmHg, and an elevated pulmonary vascular resistance (PVR) > 3 Wood units as confirmed by right heart catheterizati...

journal_title：Postgraduate medicine

authors： Velayati A,Valerio MG,Shen M,Tariq S,Lanier GM,Aronow WS

更新日期：2016-06-01 00:00:00

abstract：:Inhaled corticosteroids (ICSs) belong to the armament for treatment of chronic obstructive pulmonary disease (COPD) and as such, they are widely used in real life. This is a narrative review on evidence-based papers published in the English language listed in Medline between 1990 and March 2016 discussing ICS applicat...

journal_title：Postgraduate medicine

authors： Andreeva-Gateva PA,Stamenova E,Gatev T

更新日期：2016-06-01 00:00:00

abstract：:Hyponatremia (serum sodium <135 mEq/L) is a common electrolyte disorder in community or hospitalized patients. Serum sodium levels should be corrected at a proper rate in patients with hyponatremia, since overcorrection of serum sodium levels is related to devastating neurologic consequences, such as the osmotic demye...

journal_title：Postgraduate medicine

authors： Filippatos TD,Liamis G,Elisaf MS

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVES:Lorcaserin is a selective 5-HT2C (5-hydroxytryptamine 2C) receptor agonist indicated for weight management. Here, we assess the impact of lorcaserin on progression from prediabetes to type 2 diabetes (T2D) and on reversion from prediabetes to euglycemia. METHODS:This is a post hoc analysis of pooled data fr...

journal_title：Postgraduate medicine

authors： Nesto R,Fain R,Li Y,Shanahan W

更新日期：2016-05-01 00:00:00

abstract：:Prescription opioid analgesics are an important treatment option for patients with chronic pain; however, misuse, abuse and diversion of these medications are a major global public health concern. Prescription opioid analgesics can be abused via intended and non-intended routes of administration, both intact or after ...

journal_title：Postgraduate medicine

authors： Gasior M,Bond M,Malamut R

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVES:As the prevalence of peripheral artery disease (PAD) increases there is growing concern about the associated healthcare burden. This burden has not been well-characterized in high-risk patients with concurrent diabetes and/or acute coronary syndrome (ACS). The objective of this analysis was to assess comorbi...

journal_title：Postgraduate medicine

authors： Reed Chase M,Friedman HS,Navaratnam P,Heithoff K,Simpson RJ Jr

更新日期：2016-01-01 00:00:00

abstract：:Prompt and accurate diagnosis of patients presenting with symptoms suggestive of pulmonary arterial hypertension (PAH) is of outmost importance as delays in identifying this clinical entity have detrimental effects on both morbidity and mortality. Initial noninvasive assessment of these patients has traditionally incl...

journal_title：Postgraduate medicine

authors： Vargas PE,Lopez-Candales A

更新日期：2016-01-01 00:00:00

abstract：:Review of: Wallentin L, Becker RC, Budaj A, et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Eng J Med 2009; 361(11): 1045-1057. For acute coronary syndrome (ACS), a dual antiplatelet regimen comprised of treatment with aspirin and either P2Y12 adenosine diphosphate receptor antagonist...

journal_title：Postgraduate medicine

authors： Amico F,Amico A,Mazzoni J,Moshiyakhov M,Tamparo W

更新日期：2016-01-01 00:00:00

abstract：:Understanding the role of the kidneys in type 2 diabetes mellitus (T2DM) has taken on an increased importance in recent years with the arrival of sodium-glucose co-transporter 2 (SGLT2) inhibitors - antihyperglycemic agents (AHAs) that specifically target the kidneys. This review includes an update on the physiology o...

journal_title：Postgraduate medicine

authors： Weir MR

更新日期：2016-01-01 00:00:00

abstract：:Chronic pain is considered one of the most prevalent causes of costly and disabling medical conditions. This review will define chronic pain and its categories and then will summarize the effectiveness and side effects associated with the use of various antidepressants, including the tricyclics, the selective serotoni...

journal_title：Postgraduate medicine

authors： Khouzam HR

更新日期：2016-01-01 00:00:00

abstract：:Community-acquired pneumonia is still a significant cause of morbidity and mortality and is often misdiagnosed and inappropriately treated. Although it can be caused by a wide variety of micro-organisms, the pneumococcus, atypicals, such as Mycoplasma pneumoniae and Chlamydophila pneumoniae, Staphylococcus aureus and ...

journal_title：Postgraduate medicine

authors： Mandell LA

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Hypoglycemia and fear of hypoglycemia threaten individuals' ability to work and drive. We studied the effect of hypoglycemia on the individual and society, with a focus on possible implications of new European union legislation on patients' continued ability to drive. METHODS:A cross-sectional survey of Dan...

journal_title：Postgraduate medicine

authors： Dømgaard M,Bagger M,Rhee NA,Burton CM,Thorsteinsson B

更新日期：2015-06-01 00:00:00

abstract：:Increasing evidence has contraindicated extended radical dissection of pancreatic adenocarcinoma (PC). With the recent improvement of perioperative management techniques and multimodal treatment strategy for PC, concomitant major vessel resection and reconstruction has thus been aggressively attempted in association w...

journal_title：Postgraduate medicine

authors： Tsuchikawa T,Hirano S,Nakamura T,Okamura K,Tamoto E,Shichinohe T

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVES:Management of cardiovascular (CV) risk is an essential aspect of diabetes care, and acceptable CV risk is a requirement for antidiabetes medications. Dipeptidyl peptidase-4 (DPP-4) inhibitors effectively reduce glycated hemoglobin, with a low risk of hypoglycemia and weight gain. The purpose of this review i...

journal_title：Postgraduate medicine

authors： Ryan G

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Adults with attention-deficit/hyperactivity disorder treated with atomoxetine were examined for time-to-onset and -resolution of common treatment-emergent adverse events (TEAEs) and male sexual dysfunction, and for changes in blood pressure (BP) and heart rate (HR) upon atomoxetine discontinuation. METHODS:...

journal_title：Postgraduate medicine

authors： Upadhyaya H,Tanaka Y,Lipsius S,Kryzhanovskaya LA,Lane JR,Escobar R,Trzepacz PT,Allen AJ

更新日期：2015-01-01 00:00:00

abstract：:Some patients with severe and chronic pain fail to obtain adequate pain relief with standard pharmacologic treatment agents, including low to moderate dosages of opioids. Understandably, physicians might not believe patients who claim that a standard opioid dosage is an ineffective treatment. These patients may be sev...

journal_title：Postgraduate medicine

authors： Tennant F

更新日期：2015-01-01 00:00:00

abstract：:Transgenderism and gender dysphoria are becoming more prevalent diagnoses and the patient population is increasing. Primary care practitioners, endocrinologists, and mental health professionals are all part of the medical care team that treats these patients, but family and internal medicine physicians continue to del...

journal_title：Postgraduate medicine

authors： Wilczynski C,Emanuele MA

更新日期：2014-11-01 00:00:00

abstract：:The new oral anticoagulants have many advantages over vitamin K antagonists, but they are still associated with a troublesome incidence of major bleeding. Additionally, the absence of a reversal agent for the new oral anticoagulants is a barrier to their more widespread use. Currently, there are 3 potential reversal a...

journal_title：Postgraduate medicine

authors： Costin J,Ansell J,Laulicht B,Bakhru S,Steiner S

更新日期：2014-11-01 00:00:00

abstract：:In the next 30 years, the average age of the population will continue to increase, as will the prevalence of dementia. The management of advanced dementia requires the careful orchestration of communication, prognostication, patient care, and caregiver education. Understanding the specific tools available to establish...

journal_title：Postgraduate medicine

authors： Heron CR,Simmons BB

更新日期：2014-10-01 00:00:00

abstract：:The use of opioids for patients with chronic noncancer pain has increased dramatically, and with increasing use there is increasing concern about the potential for abuse and addiction during long-term treatment. Clinicians should avoid viewing formal or subjective risk assessment as a means of classifying patients int...

journal_title：Postgraduate medicine

authors： Gordon A,Cone EJ,DePriest AZ,Axford-Gatley RA,Passik SD

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Binge eating disorder (BED) is now a formal diagnosis in the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5). However, post-DSM-5 patient profiles and viewpoints on BED diagnosis and treatment remain unclear. This study used a focus group methodology to examine demographic and cl...

journal_title：Postgraduate medicine

authors： Herman BK,Safikhani S,Hengerer D,Atkins N Jr,Kim A,Cassidy D,Babcock T,Agus S,Lenderking WR

更新日期：2014-09-01 00:00:00

abstract：STUDY OBJECTIVES:To compare the safety and efficacy of U.S. Food and Drug Administration (FDA)-recommended doses of labetalol and nicardipine for hypertension (HTN) management in a subset of patients with renal dysfunction (RD). DESIGN:Randomized, open label, multicenter prospective clinical trial. SETTING:Thirteen U...

journal_title：Postgraduate medicine

authors： Varon J,Soto-Ruiz KM,Baumann BM,Borczuk P,Cannon CM,Chandra A,Cline DM,Diercks DB,Hiestand B,Hsu A,Jois-Bilowich P,Kaminski B,Levy P,Nowak RM,Schrock JW,Peacock WF

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Prescription opioids have substantial abuse potential. This study compared the positive subjective drug effects of a newly developed extended-release (ER) oxycodone (OC)/acetaminophen (acetyl-para-aminophenol [APAP]) formulation with those of immediate-release (IR) OC/APAP. METHODS:This randomized, double-b...

journal_title：Postgraduate medicine

authors： Morton T,Kostenbader K,Montgomery J,Devarakonda K,Barrett T,Webster L

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:In October 2012, the American College of Rheumatology (ACR) published recommendations for chronic gout treatment goals and pharmacotherapy. OBJECTIVES:Identify potential gaps between real-world chronic gout treatment, ACR guideline recommendations, and physicians' perceived guideline adherence by evaluating...

journal_title：Postgraduate medicine

authors： Oderda GM,Shiozawa A,Walsh M,Hess K,Brixner DI,Feehan M,Akhras K

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVE:To identify attitudes and practices of endocrinologists (ENDOs), family practitioners (FPs), internists (IMs), primary care nurse practitioners (NPs), physician assistants (PAs), certified diabetes educators (CDEs), retail pharmacists (R-PHs), and hospital pharmacists (H-PHs) with respect to type 2 diabetes m...

journal_title：Postgraduate medicine

authors： Williamson C,Glauser TA,Burton BS,Schneider D,Dubois AM,Patel D

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Chronic kidney disease is frequently present in patients with type 2 diabetes mellitus (T2DM). New therapeutic options in this patient subpopulation are needed. OBJECTIVES:Assess the effect of renal impairment on the pharmacokinetics (PK), efficacy, and safety of albiglutide in single- and multiple-dose stu...

journal_title：Postgraduate medicine

authors： Young MA,Wald JA,Matthews JE,Yang F,Reinhardt RR

更新日期：2014-05-01 00:00:00

abstract：AIM:To demonstrate the impact of the parathyroid hormone-related peptide (PTHrP) on the large conductance calcium-activated potassium (BKCa) channels in vascular smooth muscle cells (VSMC) and hyperpolarization of the cell membrane and its dependence on calcium. MATERIALS AND METHODS:VSMC were isolated from rat aorta ...

journal_title：Postgraduate medicine

authors： Burgazli KM,Foerster N,Meriçliler M,Chasan R,Parahuleva M,Erdogan A

更新日期：2014-03-01 00:00:00

abstract：:The compatibility of a medication with other drugs and implanted materials is an important factor impacting drug safety and efficacy. The liposomal formulation of the local anesthetic bupivacaine is designed to provide prolonged postsurgical analgesia. Its compatibility with other drugs and materials depends on the co...

journal_title：Postgraduate medicine

authors： Kharitonov V

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:To compare effects of raisin snacks with conventional snacks on glycemia and cardiovascular risk factors. MATERIALS AND METHODS:A 12-week, randomized, controlled trial compared 3-times-a-day consumption of raisins with intake of processed snacks on glycemia and cardiovascular risk factors. Men and women were...

journal_title：Postgraduate medicine

authors： Anderson JW,Weiter KM,Christian AL,Ritchey MB,Bays HE

更新日期：2014-01-01 00:00:00

abstract：:Chronic stable angina (CSA) impairs patient quality of life, is associated with increased patient mortality, and is a prominent symptom of coronary artery disease (CAD), the latter being prevalent worldwide in patients. Currently, therapeutic options for patients with CSA include β-blockers, calcium channel blockers, ...

journal_title：Postgraduate medicine

authors： Kloner RA,Hines ME,Geunes-Boyer S

更新日期：2013-11-01 00:00:00

abstract：:Our review describes potential weight-altering effects of psychotropic medications (antipsychotics, antidepressants, anti-anxiety medications, mood stabilizers, sedative-hypnotics, medications for attention-deficit/hyperactivity disorder, and other psychotropic medications) and offers guidance on switching a medicatio...

journal_title：Postgraduate medicine

authors： Hasnain M,Vieweg WV

更新日期：2013-09-01 00:00:00

abstract：:Platelets play a key role in the initiation of hemostatic mechanisms during vascular injury. When contemplating prescription of antiplatelet agents (APAs) for patients as primary prevention for cardiovascular events, the physician should carefully weigh the potential benefits of cardiovascular risk reduction with the ...

journal_title：Postgraduate medicine

authors： Acharji S,Lakshmanadoss U,Rudzinski W,Stapleton DD,Kaluski E

更新日期：2013-09-01 00:00:00

abstract：:The concurrent use of opioids, benzodiazepines (BZDs), and/or alcohol poses a formidable challenge for clinicians who manage chronic pain. While the escalating use of opioid analgesics for the treatment of chronic pain and the concomitant rise in opioid-related abuse and misuse are widely recognized trends, the contri...

journal_title：Postgraduate medicine

authors： Gudin JA,Mogali S,Jones JD,Comer SD

更新日期：2013-07-01 00:00:00